Faculty

The Ashrafi lab uses genetic, biochemical, and quantitative optical imaging techniques to study metabolic regulation of neurotransmission.

Major Lab

The Blumer lab currently studies signal transduction mechanisms that cause uveal melanoma, a highly aggressive and deadly cancer, with the ultimate goal of discovering avenues leading to effective therapy for this currently untreatable cancer.

The Chen lab utilizes multi-omic and high-throughput screening approaches to systematically investigate the regulation and function of circRNA in cells and develop novel circRNA technologies for translational applications.

The Crewe lab uses transgenic mouse lines, cell culture and biochemistry to understand extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation.

Inter-organellar interactions between midbody, centrosome, and primary cilium in health and disease.

The Djuranovic Lab uses different biochemical, molecular biology and genetics techniques to investigate the process of gene expression regulation at the level of mRNA translation.

The Goldfarb Lab is focused on computational mass spectrometry and proteomics with the goal of achieving comprehensive protein identification and quantification in complex biological samples.

Novel techniques for correcting type-1 diabetes without insulin, utilizing the beneficial effects of healthy adipose tissue: Subcutaneous transplantation of embryonic brown adipose tissue (BAT) has proven effective in reversing type 1 diabetes in mice, independent of insulin.

The He Lab is dedicated to advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

The Huettner lab uses electrophysiology to study native and recombinant mammalian glutamate receptors, in order to elucidate their interactions with components of the lipid bilayer, and their pharmacology and role in synaptic transmission.

The Jansen Lab is focused on elucidating the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions ranging from cell migration and cytokinesis to neurogenesis.

The Kast Lab studies the biogenesis and dynamics of intracellular membrane compartments; molecular mechanisms and regulation of cytoskeleton and membrane interactions.

The Klyachko Lab studies the mechanisms governing synaptic transmission are critical to our understanding of how information is transmitted in the brain, yet they remain among the most fundamental unresolved questions in neurobiology.

Molecular basis of ion channel function, and in particular on membrane lipid-channel interactions.

The Lishko Lab focuses on molecular mechanisms of bioactive lipid signaling, investigating bioelectricity and regulation of ion channels, physiology of the retina, fluid flow in the brain, fertility, reproductive biology research, neurodegeneration and vision.

The Major Lab uses mass spectrometry-based proteomics and chemical and genetic screens to study signal transduction in human disease, with a particular focus on understudied kinases and the WNT and the KEAP1/NRF2 pathways.

Structure, function and regulation of mechanosensitive ion channels.

The Nichols Lab’s research spans from the molecular basis of potassium channel activity to human disease. His work on KATP channel activity led to the discovery of the mechanism of human neonatal diabetes and a revolution in therapy – affected children can now take once a day pills – even dissolved in milk – rather than traumatic, three times a day insulin injections.

The Pagliarini Lab is an interdisciplinary team of scientists driven to understand the biochemical underpinnings of mitochondrial dysfunction in human diseases.

The Piston Lab studies the molecular pathways of islet hormone secretion.

Dr. Rosa-Molinar and his group apply to multi-scale multi-modal correlated volume resin microscopies to a systems engineering process concept known as “imaging chain” that includes determining provenance, searching, mining, processing, analyzing, displaying, storing, and managing datasets. The imaging chain enables the group to develop, refine, and use imaging tools and reagents to create image data sets required to research and unravel synapses’ three-dimensional (3-D) nano-scale geometry and molecular diversity.

WUCCI

Study several areas that focus on cell membrane function, including activation, and in-membrane dynamics of BCl-2 family proteins, the critical arbiters of cell death in humans, pore forming antimicrobial peptides, membrane repair, perflurocarbon nano-delivery systems, malaria parasite host/cell interactions.

The Stewart lab’s research focuses on understanding how age-related changes in noncancerous cells (referred to as stroma) participate in cancer development.

The Stratman Lab studies the mechanisms regulating blood vessel formation, stabilization, and blood flow sensing during development and disease.

The True Lab studies protein misfolding and aggregation are the hallmark of several neurodegenerative diseases and other disorders.

Impact of gain- and loss-of-function in K_ATP on smooth muscle cell electrophysiology.

The You Lab studies the DNA damage response and replication stress response in human cells that are essential for genome maintenance and cancer avoidance.

Mass Spectrometry, Proteomics