Recent Publications
Mitochondrial proteome research: the road ahead (Links to an external site)
Baker ZN, Forny P, and Pagliarini DJ
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC (Links to an external site)
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le Q-T, Goldfarb D, and Major MB
Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders (Links to an external site)
Quinta HR, Ibanez L, Cruchaga C, and Maschi D
Browse publications by year
Mitochondrial proteome research: the road ahead (Links to an external site)
Baker ZN, Forny P, and Pagliarini DJ
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC (Links to an external site)
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le Q-T, Goldfarb D, and Major MB
Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders (Links to an external site)
Quinta HR, Ibanez L, Cruchaga C, and Maschi D
Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells (Links to an external site)
Gao J, McClenaghan C, Matreyek KA, Grange DK, and Nichols CG
Subunit gating resulting from individual protonation events in Kir2 channels (Links to an external site)
Maksaev G, Brundl-Jirout M, Stary-Weinzinger A, Zangerl-Plessl E-M, Lee S-J, and Nichols CG
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment (Links to an external site)
Tan K, Song Y, Xu M, and You Z
Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles (Links to an external site)
Crewe C
Mitochondrial uncouplers impair human sperm motility without altering ATP content (Links to an external site)
Skinner WM, Petersen NT, Unger B, Tang S, Tabarsi E, Lamm J, Jalalian L, Smith J, Bertholet AM, Xu K, Kirichok Y, and Lishko PV
Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis (Links to an external site)
Mason DE, Goeckel M. Vega SL, Wu P-H, Johnson D, Heo S-J, Wirtz D, Burdick JA, Wood L, Chow B, Stratman AN, and Boerckel JD
Scanning electron microscopy of human islet cilia (Links to an external site)
Polino AJ, Sviben S, Melena I, and Hughes JW
Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses (Links to an external site)
Malagon G, Myeong J, and Klyachko VA
Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS (Links to an external site)
McClenaghan C, Mukadam MA, Roeglin J, Tryon RC, Grabner M, Dayal A, Meyer GA, and Nichols CG
Isolation of Adipose Tissue Extracellular Vesicles (Links to an external site)
Sabio JM, and Crewe C
Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function (Links to an external site)
Davis MJ, Castorena-Gonzalez JA, Jin Kim H, Li M, Remedi M, and Nichols CG
Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function (Links to an external site)
Haoui M, Vergara C, and Lishko PV
Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels (Links to an external site)
Lee S-J, Maeda S, Gao J, and Nichols CG
Untangling the connection between stress and metastatic breast cancer (Links to an external site)
He X-Y, Ng D, Gao Y, Michalopoulou E, George S, Adrover J, Sun L, Albrengues J, Wan L, Han X, Vakoc CR, Van Aelst L, and Egeblad M.
Blockade of TRPV channels by intracellular spermine (Links to an external site)
Maksaev G, Yuan P, and Nichols CG
p38MAPKa stromal reprogramming sensitizes metastatic breast cancer to immunotherapy (Links to an external site)
Faget DV, Luo X, Inkman MJ, Ren Q, Su X, Ding K, Waters MR, Raut GK, Pandey G, Dodhiawala PB, Ramalho-Oliveira R, Ye J, Cole T, Murali B, Zheleznyak A, Shokeen M, Weiss KR, Monahan JB, DeSelm CJ, Lee AV, Oesterreich S, Weilbaecher KN, Zhang J, DeNardo DG, and Stewart SA
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks (Links to an external site)
Li S, Kong L, Meng Y, Cheng C, Lemacon DS, Yang Z, Tan K, Cheruiyot A, Lu Z, and You Z
Aim18p and Aim46p are chalcone isomerase (CHI)-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae (Links to an external site)
Schmitz JM, Wolters JF, Murray NH, Guerra RM, Bingman CA, Hittinger CT, and Pagliarini DJ
The NTPase activity of the double FYVE domain–containing protein 1 regulates lipid droplet metabolism (Links to an external site)
Ismail VA, Naismith T, and Kast DJ
Coenzyme Q biochemistry and biosynthesis (Links to an external site)
Guerra RM, and Pagliarini DJ
Glucokinase Inhibition: A Novel Treatment for Diabetes? (Links to an external site)
Remedi MS, and Nichols CG
Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters (Links to an external site)
Matamoros M, Ng XW, Brettmann JB, Piston DW, and Nichols CG
Personalized therapeutics for KATP-dependent pathologies (Links to an external site)
Nichols CG
A unique high-output cardiac hypertrophy phenotype arising from low systemic vascular resistance in Cantu Syndrome (Links to an external site)
Singh GK, McClenaghan C, Aggarwal M, Gu H, Remedi MS, Grange DK, and Nichols CG
Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses (Links to an external site)
Myeong J, and Klyachko V
Genome-edited zebrafish model of ABCC8 loss-of-function disease (Links to an external site)
Ikle JM, Tryon RC, Singareddy SS, York NW, Remedi MS, and Nichols CG
Structure and functionality of a multimeric human COQ7:COQ9 complex (Links to an external site)
Manicki M, Aydin H, Abriata LA, Overmyer KA, Guerra RM, Coon JJ, Dal Peraro M, Frost A, and Pagliarini DJ
N-terminal acetylation and arginylation of actin determines the architecture and assembly rate of linear and branched actin networks (Links to an external site)
Chin SM, Hatano T, Sivashanmugam L, Suchenko A, Kashina AS, Balasubramanian MK, and Jansen S
Small-molecule inhibition of the archetypal UbiB protein COQ8 (Links to an external site)
Murray NH, Asquith CR, Fang Z, Smith RW, Vasta JD, Zimprich CA, Corona CR, Robers MB, Bingman CA, and Pagliarini DJ
KATP channels in lymphatic function (Links to an external site)
Davis MJ, Kim HJ, and Nichols CG
Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior (Links to an external site)
Abello J, Raghavan S, Yien YY, and Stratman AN
Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors (Links to an external site)
Bhadra AK, Rau MJ, Daw JA, Fitzpatrick JAJ, Weihl CC, and True HL
Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress (Links to an external site)
Yang Z, Lemacon DS, Li S, Cheruiyot A, Kong L, Tan K, Cheng C, Turkay E, He D, and You Z
2-propylphenol allosterically modulates COQ8A to enhance ATPase activity (Links to an external site)
Murray NH, Lewis A, Pabon JPR, Gross ML, Henzler-Wildman K, and Pagliarini DJ
Deficient caveolin-1 synthesis in adipocytes stimulates systemic insulin-independent glucose uptake via extracellular vesicles (Links to an external site)
Crewe C, Chen S, Bu D, Gliniak CM, Wernstedt Asterholm I, Yu XX, Joffin N, de Souza CO, Funcke JB, Oh DY, Varlamov O, Robino JJ, Gordillo R, and Scherer PE
Enabling hotspot detection and public health response to the COVID-19 pandemic (Links to an external site)
Foraker R, Landman J, Lackey I, Haslam MD, Antes AL, and Goldfarb D
Semiautomated analysis of an optical ATP indicator in neurons (Links to an external site)
Dehkharghanian T, Hashemiaghdam A, and Ashrafi G
The challenges of interrogating adipose tissue extracellular vesicle functions in physiology (Links to an external site)
Crewe C
Stress response regulates cancer fibroblasts (Links to an external site)
Faget DV, and Stewart SA
Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling (Links to an external site)
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB
Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling (Links to an external site)
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB
Association of the receptor for activated C-kinase 1 (RACK1) with ribosomes in Plasmodium falciparum (Links to an external site)
Erath J, and Djuranovic S
Defining mitochondrial protein functions through deep multiomic profiling (Links to an external site)
Rensvold JW, Shishkova E, Sverchkov Y, Miller IJ, Cetinkaya A, Pyle A, Manicki M, Brademan DR, Alanay Y, Raiman J, Jochem A, Hutchins PD, Peters SR, Linke V, Overmyer KA, Salome AZ, Hebert AS, Vincent CE, Kwiecien NW, Rush MJP, Westphall MS, Craven M, Akarsu NA, Taylor RW, Coon JJ, and Pagliarini DJ
FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells (Links to an external site)
Deng PY, Kumar A, Cavalli V, and Klyachko VA
The microenvironment-a general hypothesis on the homeostatic function of extracellular vesicles (Links to an external site)
Stratman AN, Crewe C, and Stahl PD
Caught in a web: emerging roles of neutrophil extracellular traps in cancer (Links to an external site)
He X-Y, Ng D, and Egeblad M.
High-throughput methodology to identify CRISPR-generated Danio rerio mutants using fragment analysis with unmodified PCR products (Links to an external site)
Colijn S, Yin Y, and Stratman AN
ATP-sensitive potassium channels in hyperinsulinism and type 2 diabetes: Inconvenient paradox or new paradigm? (Links to an external site)
Nichols CG, York NW, and Remedi MS
Modulation of miRISC-mediated gene silencing in eukaryotes (Links to an external site)
Jungers CF, and Djuranovic S
The GTPase activity of the Double FYVE Domain Containing Protein I (DFCPI) regulates liquid droplet metabolism (Links to an external site)
Ismail VA, Naismith T, and Kast DJ
Isolation of cardiac and vascular smooth muscle cells from adult, juvenile, larval and embryonic zebrafish for electrophysiological studies (Links to an external site)
Singareddy SS, McClenaghan C, Roessler HI, Tryon R, and Nichols CG
Gene expression predicts dormant metastatic breast cancer cell phenotype (Links to an external site)
Ren Q, Khoo WH, Corr AP, Phan TG, Croucher PI, and Stewart SA
Bridging personal and population in excitability diseases: Will studies of rare diseases bring generalizable mechanisms from monogenic channelopathies? (Links to an external site)
Nichols CG, and McClenaghan C
Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma (Links to an external site)
Onken MD, Noda SE, Kaltenbronn KM, Frankfater C, Makepeace CM, Fettig N, Piggott KD, Custer PL, Ippolito JE, and Blumer KJ
Hyperexcitability of sensory neurons in fragile x mouse model (Links to an external site)
Deng PY, Avraham O, Cavalli V, and Klyachko VA
Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function (Links to an external site)
Rosier K, McDevitt MT, Smet J, Floyd BJ, Verschoore M, Marcaida MJ, Bingman CA, Lemmens I, Peraro MD, Tavernier J, Cravatt BF, Gounko NV, Vints K, Monnens Y, Bhalla K, Aerts L, Rashan EH, Vanlander AV, Coster RV, Régal L, Pagliarini DJ, and Creemers JWM
Gene dosage effects of poly(A) track-engineered hypomorphs (Links to an external site)
Powell G, Pavlovic-Djuranovic S, and Djuranovic S
ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle (Links to an external site)
Singareddy SS, Roessler HI, McClenaghan C, Ikle JM, Tryon RC, van Haaften G, and Nichols CG
Structured elements drive extensive circular RNA translation (Links to an external site)
Chen C-K, Cheng R, Demeter J, Chen J, Weingarten-Gabbay S, Jiang L, Snyder MP, Weissman JS, Segal E, Jackson PK, and Chang HY
Tissue-specific smooth muscle cell subtypes identified by transcriptional profiling (Links to an external site)
Lin CJ, and Mecham BP
Vascular smooth muscle cell subpopulations and neointimal formation in mouse models of elastin insufficiency (Links to an external site)
Lin CJ, Hunkins BM, Roth RA, Lin CY, Wagenseil JE, and Mecham RP
Alpha/beta hydrolase domain-containing protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle (Links to an external site)
Bjorkgren I, Chung DH, Mendoza S, Gabelev-Khasin L, Petersen NT, Modzelewski A, He L, and Lishko PV
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes (Links to an external site)
Crewe C, Funcke JB, Li S, Joffin N, Gliniak CM, Ghaben AL, An YA, Sadek HA, Gordillo R, Akgul Y, Chen S, Samovski D, Fischer-Posovsky P, Kusminski CM, Klein S, and Scherer PE
Nonsense-mediated RNA decay is a unique vulnerability of cancer cells harboring SF3B1 or U2AF1 mutations (Links to an external site)
Cheruiyot A, Li S, Srivatsan SN, Ahmed T, Chen Y, Lemacon DS, Li Y, Yang Z, Wadugu BA, Warner WA, Pruett-Miller SM, Obeng EA, Link DC, He D, Xiao F, Wang X, Bailis JM, Walter MJ, and You Z
The epithelial potassium channel Kir7.1 is stimulated by progesterone (Links to an external site)
Bjorkgren I, Mendoza S, Chung DH, Haoui M, Petersen NT, and Lishko PV
Mitochondria in neuronal health: From energy metabolism to Parkinson’s disease (Links to an external site)
Mahadevan HM, Hashemiaghdam A, Ashrafi G, and Harbauer AB
UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae (Links to an external site)
Kemmerer ZA, Robinson KP, Schmitz JM, Manicki M, Paulson BR, Jochem A, Hutchins PD, Coon JJ, and Pagliarini DJ
The extensive and functionally uncharacterized mitochondrial phosphoproteome (Links to an external site)
Niemi NM, and Pagliarini DJ
Targeting primary and metastatic uveal melanoma with a G protein inhibitor (Links to an external site)
Onken MD, Makepeace CM, Kaltenbronn KM, Choi J, Hernandez-Aya L, Weilbaecher KN, Piggot KD, Kumar Rao P, Yuede CM, Dixon AJ, Osei-Owusu P, Cooper JA, and Blumer KJ
Defining intermediates and redundancies in conenzyme Q precursor biosynthesis (Links to an external site)
Robinson KP, Jochem A, Johnson SE, Reddy TR, Russell JD, Coon JJ, and Pagliarini DJ
Myosin V Regulates Spatial Localization of Different Form of Neurotransmitter Release in Central Synapses (Links to an external site)
Maschi D, Gramlich MW, and Klyachko VA
Channelopathies in fragile X syndrome (Links to an external site)
Deng PY, and Klyachko KA
Choroid plexus epithelial cells as a model to study nongenomic steroid signaling and its effect on ion channel function (Links to an external site)
Haoui M, Petersen NT, Bjorkgren I, Chung DH, and Lishko PV
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel (Links to an external site)
Matamoros M, and Nichols CG
Recording electrical currents across the plasma membrane of mammalian sperm cells (Links to an external site)
Liu B, Mundt N, Miller M, Clapham DE, Kirichok Y, and Lishko PV
Complex consequences of Cantú syndrome SUR2 variant R1154Q in genetically modified mice (Links to an external site)
Zhang H, Hanson A, Scherf de Almeida T, Emfinger C, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, and Nichols CG