Colin G. Nichols, PhD

Carl Cori Professor, Department of Cell Biology & Physiology
Director, Center for the Investigation of Membrane Excitability Diseases

Research Interests

Colin’s research spans from the molecular basis of potassium channel activity to human disease. His work on KATP channel activity led to the discovery of the mechanism of human neonatal diabetes and a revolution in therapy – affected children can now take once a day pills – even dissolved in milk – rather than traumatic, three times a day insulin injections.

Professional Education
  • BSc: Leeds University (England), 1982, Biochemistry & Physiology
  • PhD: Leeds University (England), 1985, Physiology
Paula Reynolds, Adminstrative Coordinator, CIMED
  • Office Location: 9611 BJCIH
    Phone: 314-286-1758; Fax: 314-362-2244

Nichols Lab

BJC Institute of Health

Research in my laboratory is focused on the biology of ion channels. We develop, introduce and use a wide range of molecular biological and biophysical approaches, as well as in vivo gene manipulation to address questions in proteins, cells and animals, and now in humans. These efforts are leading us to detailed understanding of both molecular mechanisms of channel activity, and roles of ion channels in multiple disease processes including diabetes, heart failure, pulmonary disease and epilepsy.