Colin G. Nichols, PhD
Carl Cori Professor, Department of Cell Biology and Physiology
Director, Center for the Investigation of Membrane Excitability Diseases
- Phone: 314-362-7463
- Email: cnichols@wustl.edu
Research Interests
Colin’s research spans from the molecular basis of potassium channel activity to human disease. His work on KATP channel activity led to the discovery of the mechanism of human neonatal diabetes and a revolution in therapy – affected children can now take once a day pills – even dissolved in milk – rather than traumatic, three times a day insulin injections.
Professional Education
- BSc: Leeds University, England, 1982, Biochemistry & Physiology
- PhD: Leeds University, England, 1985, Physiology
Graduate & Fellowship Program Affiliations
Links
Paula Reynolds, Adminstrative Coordinator, CIMED
- Office Location: 9611 BJCIH
Phone: 314-286-1758; Fax: 314-362-2244
Email: paula@wustl.edu
Publications
ATP-Sensitive potassium channels in hyperinsulinism and type 2 diabetes: Inconvenient paradox or new paradigm? (Links to an external site)
Nichols CG, York NW, and Remed MS
Isolation of cardiac and vascular smooth muscle cells from adult, juvenile, larval and embryonic zebrafish for electrophysiological studies (Links to an external site)
Singareddy SS, McClenaghan C, Roessler HI, Tryon R, and Nichols CG
Bridging personal and population in excitability diseases: Will studies of rare diseases bring generalizable mechanisms from monogenic channelopathies? (Links to an external site)
ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle (Links to an external site)
Singareddy SS, Roessler HI, McClenaghan C, Ikle JM, Tryon RC, van Haaften G, Nichols CG
Pore-forming transmembrane domains control ion selectivity and selectivity filter conformation in the KirBac1.1 potassium channel (Links to an external site)
Matamoros M and Nichols CG
Complex consequences of Cantú syndrome SUR2 variant R1154Q in genetically modified mice (Links to an external site)
Zhang H, Hanson A, Scherf de Almeida T, Emfinger C, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, and Nichols CG
Kir6.1-SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome (Links to an external site)
York NW, Parker H, Xie Z, Tyus D, Waheed MA, Yan ZH, Grange DK, Remedi MS, England SK, Hu H, and Nichols CG
Coronavirus proteins as ion channels: Current and potential research (Links to an external site)
McClenaghan C, Hanson A, Lee SJ, and Nichols CG
The mechanism of high-output cardiac hypertrophy arising from potassium channel gain-of-function in Cantú syndrome (Links to an external site)
McClenaghan C, Huang Y, Matkovich SJ, Kovacs A, Weinheimer CJ, Perez R, Broekelmann TJ, Harter TM, Lee J-M, Remedi MS, and Nichols CG