Kendall Blumer, PhD
Professor of Cell Biology & Physiology
- Phone: 314-362-1668
- Email: kblumer@wustl.edu
Research Interests
The Blumer lab currently studies signal transduction mechanisms that cause uveal melanoma, a highly aggressive and deadly cancer, with the ultimate goal of discovering avenues leading to effective therapy for this currently untreatable cancer.
Professional Education
- BA: Rice University, 1977, Biochemistry
- PhD: Duke University, 1986, Biochemistry
- Postdoc: University of California-Berkeley, 1989, Biochemistry
Graduate & Fellowship Program Affiliations
Links
Blumer Lab
McDonnell Sciences Building
314-362-1662
kblumer@wustl.edu
Tumor Cell Signaling | Metabolomics | Proteomics | Transcriptomics | CRISPR screens | Molecular and Whole-Animal Imaging | Single-Molecule Biophysics | Targeted Therapy Development | Synthetic Organic Chemistry
The Blumer lab studies oncogenic signaling by mutationally activated heterotrimeric G proteins. Our ongoing research: 1) determines how oncogenic G proteins drive tumor formation, growth, invasion, survival, and metabolism; 2) establishes oncogenic G proteins as pharmacological targets for cancer therapy; and 3) designs and synthesizes G protein inhibitors for preclinical studies and, eventually, clinical trials. Much of our work focuses on metastatic uveal (ocular) melanoma because it is highly aggressive, deadly and untreatable, and nearly always driven by oncogenic G proteins