
Vitaly A. Klyachko, PhD
Professor of Cell Biology & Physiology
- Phone: 314-362-5517
- Email: klyachko@wustl.edu
Research Interests
The mechanisms governing synaptic transmission are critical to our understanding of how information is transmitted in the brain, yet they remain among the most fundamental unresolved questions in neurobiology. Numerous presynaptic processes are often affected in neurological diseases, including Fragile X syndrome and Alzheimer’s disease. Direct examination of presynaptic processes has historically been limited by the resolution constraints of conventional approaches. The long-term goal of my research program is to develop and apply nanoscale resolution approaches to understand the fundamental mechanisms of synaptic transmission in central synapses under normal conditions, and what disruptions lead to disease states.
Professional Education
- BS: Moscow State University, Russia, 1997, Physics
- MS: Moscow State University, Russia, 1998, Biophysics
- PhD: University of Wisconsin-Madison, Madison, WI, 2002, Biophysics
- Postdoc: HHMI, Salk Institute, La Jolla, CA , 2002-2007, Neuroscience
Graduate & Fellowship Program Affiliations
Publications
Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses (Links to an external site)
FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells (Links to an external site)
Deng PY, Kumar A, Cavalli V, and Klyachko VA
Hyperexcitability of sensory neurons in fragile x mouse model (Links to an external site)
Deng PY, Avraham O, Cavalli V, and Klyachko VA
Myosin V Regulates Spatial Localization of Different Form of Neurotransmitter Release in Central Synapses (Links to an external site)
Maschi D, Gramlich MW, and Klyachko VA
Channelopathies in fragile X syndrome (Links to an external site)
Deng PY and Klyachko KA
Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites in central synapses (Links to an external site)
Maschi D and Klyachko VA