David J. Pagliarini, PhD

Hugo F. & Ina C. Urbauer Professor and BJC Investigator
Departments of Cell Biology & Physiology, Biochemistry and Molecular Biophysics, and Genetics

Research Interests

We are an interdisciplinary team of scientists driven to understand the biochemical underpinnings of mitochondrial dysfunction in human diseases. Together, we integrate large-scale methodologies with traditional biochemistry to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

Professional Education
  • BS: University of Notre Dame, 1999, Biochemistry
  • MS: University of Michigan, 2002, Biological Chemistry
  • PhD: University of California-San Diego, 2005, Biomolecular Sciences
  • Postdoc: Harvard Medical School, 2005-2009

Pagliarini Lab

Couch Biomedical Research Building (MS: 8228-0041-01)

Mitochondrial Metabolism | Protein Biochemistry | Chemical Biology | Systems Genetics | Rare Diseases

Mitochondria are complex and dynamic organelles that are home to a vast array of essential metabolic pathways and processes and whose dysfunction underlies hundreds of human diseases. Despite this, much of the basic biology of these organelles remains obscure, and therapeutic options to treat mitochondrial dysfunction remain woefully inadequate. By blending classic biochemistry, molecular & cellular biology, and genetics with large-scale proteomics and systems approaches, our lab aims to systematically define the functions of uncharacterized mitochondrial proteins, identify new gene mutations that underlie human disease, and explore new molecular therapeutics to rectify mitochondria-based disorders.