Our lab studies the DNA damage response and replication stress response in human cells that are essential for genome maintenance and cancer avoidance. We are also interested in the connection between genome maintenance and RNA surveillance, focusing on the nonsense-mediated RNA decay (NMD) pathway in the DNA damage response. We employ a range of techniques, including cell imaging with genetically encoded reporters, laser microirradiation and genome-wide CRISPR-Cas9 screens, to identify new mechanisms of DNA and RNA surveillance systems, with the goal of improving the understanding and treatment of cancer.
- BS: Zhejiang University (China), 1994, Biology
- MS: Shanghai Institute of Biochemistry, Chinese Academy of Sciences, 1997, Molecular Biology
- PhD: University of California – San Diego, 2002, Biochemistry
- Postdoc: Salk Institute, California, La Jolla, 2002-2009, Cell Biology
McDonnell Sciences Building (MS: 8228-0012-05)
Replication Stress Response | DNA Damage Response | Nonsense-mediated RNA Decay (NMD)
We study molecular mechanisms that maintain genomic stability, focusing on DNA damage and replication stress responses and their relations to cancer formation and treatment. We also develop research tools for the NMD RNA surveillance pathway and investigate its intersection with genome maintenance pathways and its potential as a therapeutic target for specific hematological malignancies.