Vitaly A. Klyachko, PhD

Professor of Cell Biology & Physiology

Phone: 314-362-5517
Email: klyachko@nospam.wustl.edu

The Klyachko Lab studies the mechanisms governing synaptic transmission are critical to our understanding of how information is transmitted in the brain, yet they remain among the most fundamental unresolved questions in neurobiology.

Research Interests

The mechanisms governing synaptic transmission are critical to our understanding of how information is transmitted in the brain, yet they remain among the most fundamental unresolved questions in neurobiology. Numerous presynaptic processes are often affected in neurological diseases, including Fragile X syndrome and Alzheimer’s disease. Direct examination of presynaptic processes has historically been limited by the resolution constraints of conventional approaches. The long-term goal of my research program is to develop and apply nanoscale resolution approaches to understand the fundamental mechanisms of synaptic transmission in central synapses under normal conditions, and what disruptions lead to disease states.

Professional Education

BS: Moscow State University, Russia, 1997, Physics
MS: Moscow State University, Russia, 1998, Biophysics
PhD: University of Wisconsin-Madison, 2002, Biophysics
Postdoc: HHMI, Salk Institute, 2002-2007, Neuroscience

Graduate & Fellowship Program Affiliations

Neurosciences Program

Klyachko Lab

McDonnell Sciences Building (MS: 8228-0012-05)
314-362-5518
klyachko@wustl.edu

The goal of our research program is to develop and apply nanoscale resolution approaches to understand the fundamental mechanisms of synaptic transmission in central synapses under normal conditions, and how disruptions in synaptic functions lead to disease states, particularly Fragile X syndrome and Alzheimer’s disease.