James E. Huettner, PhD

Professor of Cell Biology & Physiology

Research Interests

The Huettner lab uses electrophysiology to study native and recombinant mammalian glutamate receptors, in order to elucidate their interactions with components of the lipid bilayer, and their pharmacology and role in synaptic transmission.

Professional Education
  • BS: Indiana University of Pennsylvania, 1980, Biology
  • BA: Indiana University of Pennsylvania, 1981, Physics
  • PhD: Harvard University, 1987, Neurobiology
  • Postdoc: Harvard University, 1987-1990, Neurobiology

Huettner Lab

South Building (MS: 8228-0003-04)

Glutamate Receptors | Electrophysiology | Stem Cell Differentiation

We use electrophysiology to analyze neuronal synaptic function with a major emphasis on native and recombinant mammalian glutamate receptors. Our goal is to identify and characterize subtype-selective antagonists and allosteric modulators that enable dissection of the functional role played by specific receptor isoforms. We also study the differentiation of mouse and human embryonic stem cell and induced pluripotent stem cells into neurons in vitro, with a focus on assessing their terminally differentiated physiological characteristics.