The Huettner lab uses electrophysiology to study native and recombinant mammalian glutamate receptors, in order to elucidate their interactions with components of the lipid bilayer, and their pharmacology and role in synaptic transmission.
- BS: Indiana University of Pennsylvania, 1980, Biology
- BA: Indiana University of Pennsylvania, 1981, Physics
- PhD: Harvard University, 1987, Neurobiology
Graduate & Fellowship Program Affiliations
Glutamate Receptors | Electrophysiology | Stem Cell Differentiation
We use electrophysiology to analyze neuronal synaptic function with a major emphasis on native and recombinant mammalian glutamate receptors. Our goal is to identify and characterize subtype-selective antagonists and allosteric modulators that enable dissection of the functional role played by specific receptor isoforms. We also study the differentiation of mouse and human embryonic stem cell and induced pluripotent stem cells into neurons in vitro, with a focus on assessing their terminally differentiated physiological characteristics.