Pan-Yue Deng, MD, PhD
Associate Professor of Cell Biology & Physiology
- Phone: 314-362-5518
- Email: pydeng@nospam.wustl.edu
Professional Education
- BS: Hunan Medical University (China), 1995, Clinical Medicine
- MS: Central South University (China), 2001, Neurobiology
- PhD: Central South University (China), 2004, Pharmacology
- Postdoc: University of North Dakota, 2005-2009
Laboratory Affiliation
Links
Klyachko Lab
McDonnell Sciences Building (MS: 8228-0012-05)
314-362-5518
klyachko@wustl.edu
Synaptic Transmission | Neurotransmitter Release | Fragile X Syndrome | FMRP | Autism | GABAergic Inhibition | Neural Circuits | Super Resolution Microscopy | Electrophysiology | Modeling
The goal of our research program is to develop and apply nanoscale resolution approaches to understand the fundamental mechanisms of synaptic transmission in central synapses under normal conditions, and how disruptions in synaptic functions lead to disease states, particularly Fragile X syndrome and Alzheimer’s disease.
Publications
Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model (Links to an external site)
Deng P-Y, Kumar A, Cavalli V, and Klyachko VA
FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells (Links to an external site)
Deng PY, Kumar A, Cavalli V, and Klyachko VA
Hyperexcitability of sensory neurons in fragile x mouse model (Links to an external site)
Deng PY, Avraham O, Cavalli V, and Klyachko VA
Channelopathies in fragile X syndrome (Links to an external site)
Deng PY, and Klyachko KA