Centers

Reflecting increased awareness of the role of electrical excitability and the myriad of diseases now linked directly to derangements in membrane excitability, CIMED will pull together scientists from different disciplines with a fundamental interest in excitability diseases. With the unified theme of the Center, CIMED investigators will be uniquely positioned to provide fundamental insights into membrane excitability disease mechanisms, and to the development of novel therapeutics.

Extracellular Vesicles | Exosomes | Adipose Tissue | Obesity | Diabetes | Metabolism

The Crewe lab uses transgenic mouse lines, cell culture and biochemistry to understand extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation. Our work has uncovered the existence of an expansive EV-mediated signaling network within the adipose tissue proper, and from the adipose tissue to other organs. This mostly adipocyte-derived EV population consists of exosome-like vesicles that carry proteins, RNAs and lipid species that can modulate a variety of signaling pathways in recipient cells. The focus of the lab is to determine how the various cargo of adipocyte EVs signal within the adipose tissue and from the adipose tissue to distal organs to modulate metabolism in obesity.

The mission of the Washington University School of Medicine Diabetes Research Center is to support and enhance research in diabetes and related metabolic diseases. Now in its 45th year of continuous NIDDK funding, this DRC is located at an outstanding research institution with a longstanding tradition of excellence in diabetes investigation. The mission of the Washington University School of Medicine Diabetes Research Center is to support and enhance research in diabetes and related metabolic diseases. Now in its 45th year of continuous NIDDK funding, this DRC is located at an outstanding research institution with a longstanding tradition of excellence in diabetes investigation.

Hope Center laboratories study a range of nervous system diseases with the common feature of neurodegeneration or death of nerve cells. These include chronic or degenerative diseases such as amyotrophic lateral sclerosis (Lou Gehrig’s disease), Alzheimer’s disease, epilepsy, multiple sclerosis, muscular dystrophy and Parkinson’s disease as well as acute conditions such as stroke, cerebral palsy, and spinal cord injury. Advances in basic and applied neuroscience offer new hope for discovery of effective therapies for many of these conditions.  The Center builds upon the idea that scientific principles of nervous system degeneration and repair are shared by many different neurological diseases. This vision has led to creation of a multi-departmental research environment that fosters outstanding interdisciplinary collaboration.

We’re committed to providing the best mass spectrometry-based research both cost-effectively and quickly. We provide an initial consultation at no charge to review each project and offer continued consultation to ensure successful outcomes. The MTAC offers many services from simple protein identification to protein quantitation (both relative and absolute) by bottom-up proteomics analyses. The MTAC provides intact, native, top-down proteomics analyses. The Center specializes in providing global quantitative post-translational-modification (PTM) analysis (Phosphorylation, Ubiquitination, Acetylation, Methylation) along with epiproteomics Histone PTM assay. The MTAC develops new targeted metabolomics/lipidomics panels as well as fully supports spatial proteome/metabolome imaging mass spectrometry.

The ICCE Institute (Integrating Communication within the Cancer Environment) is dedicated to determining how interactions between tumor cells and their cellular, biochemical, and structural environment facilitates tumor progression and metastasis. The Institute is primarily a discovery-based cancer research group that has been structured to be able to rapidly translate breakthroughs into patient care through molecular and cellular cancer biology, molecular imaging, and functional genomics.

The overarching goal of the Center for Cellular Imaging (WUCCI) is to provide reliable and affordable access to state-of-the-art cellular imaging technologies, provide professional guidance in experimental design, sample preparation and data analysis, develop and apply new imaging technologies and work collaboratively with Wash U researchers to advance our understanding of human health and disease.