My current focus is on molecular mechanisms of ion channels and transporters that play essential roles in human physiology.
- BS: University of Science and Technology of China, Physics
- PhD: University of Pennsylvania, Biochemistry and Molecular Biophysics
- Postdoc: The Rockefeller University, Laboratory of Molecular Neurobiology and Biophysics
BJC Institute of Health, Room 9608
Membrane Transport | Channels | Transporters | X-Ray | Cryo-EM | Electrophysiology
Selective transport of ions, nutrients, and folded proteins across cell membranes, mediated by membrane transport proteins, is a fundamental biological process. I am interested in understanding molecular mechanisms of membrane transport proteins such as ion channels and transporters that play essential roles in physiology and disease. How do ion channels and transporters recognize their specific substrate ions? How do channels open and close their ion conduction pores in response to environmental cues and cellular stimuli such as chemicals, temperature, membrane voltage and mechanical force? To answer these fundamental questions, my lab uses multidisciplinary approaches including electrophysiology, biochemical and biophysical assays, and structural biology. Dysfunction of these membrane proteins leads to a wide range of diseases, including asthma, hypertension, cancer, heart failure, diabetes and chronic pain. My long-term goal is to advance our understanding of structure and function of these essential membrane proteins at the atomic level and establish new foundations for rational therapies.