
Michael Benjamin Major, PhD
Professor of Cell Biology & Physiology
- Phone: 314-273-3675
- Email: bmajor@wustl.edu
Research Interests
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer.
Professional Education
- Coming soon
Links
Major Lab
McDonnell Sciences Building
314-273-3669
bmajor@wustl.edu
Signal Transduction | Mass Spectrometry | Integrative OMICs | Cancer | Clinical Proteomics | Kinases
We study how alterations in signal transduction leads to human disease. We start with a “systems level” integrative discovery platform, one that has as a foundation mass spectrometry-based proteomics. Chemical and genetic functional screens enrich the proteomic metworks to yield disease-annotated physical/functional maps for signaling pathways of interest. The models and hypotheses produced are challenged through mechanistic and phenotypic studies employing cultured human cells in 2D and 3D, mouse models, clinical samples and in vitro biochemical systems. We have longstanding interest in the Wnt pathway and the KEAP1/NRF2 oxidative stress response pathway, as well as kinases and ubiquitin ligases.
Publications
Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling (Links to an external site)
Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor (Links to an external site)
Tamir TY, Bowman BM, Agajanian MJ, Goldfarb D, Schrank TP, Stohrer T, Hale AE, Siesser PF, Weir SJ, Murphy RM, LaPak KM, Weissman BE, Moorman NJ, and Major MB