You Lab

McDonnell Sciences Building, Room 514
314-362-4668
zyou@wustl.edu

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Replication Stress Response | DNA Damage Response | Nonsense-mediated RNA Decay (NMD)

We study molecular mechanisms that maintain genomic stability, focusing on DNA damage and replication stress responses and their relations to cancer formation and treatment. We also develop research tools for the NMD RNA surveillance pathway and investigate its intersection with genome maintenance pathways and its potential as a therapeutic target for specific hematological malignancies.