McDonnell Sciences Building (MS: 8228-0012-04)
Vascular Development | Cardiovascular Disease | Mechanobiology | Biophysical Regulation of Transcript/Gene Expression | Zebrafish | Live Time-Lapse Imaging | CRISPR Mutagenesis | Cell Signaling | Tissue Patterning | In Vitro Modeling
The Stratman lab studies signaling pathways regulating vascular development using zebrafish as a model system. Our ongoing research aims to understand how biomechanical forces, such as changes in tissue microenvironment or blood flow state, affect vascular patterning, signaling, and stabilization. Current lab projects focus on 1) the role of vascular primary cilia as mechanosensors, 2) the role of mechanical sensitive ion channels in regulating vascular stabilization, and 3) the role of endocytic trafficking and EVs in communication between the vasculature and the microenvironment.