Huettner Lab

Glutamate Receptors | Electrophysiology | Stem Cell Differentiation

We use electrophysiology to analyze neuronal synaptic function with a major emphasis on native and recombinant mammalian glutamate receptors. Our goal is to identify and characterize subtype-selective antagonists and allosteric modulators that enable dissection of the functional role played by specific receptor isoforms. We also study the differentiation of mouse and human embryonic stem cell and induced pluripotent stem cells into neurons in vitro, with a focus on assessing their terminally differentiated physiological characteristics.