Extracellular Vesicles | Exosomes | Adipose Tissue | Obesity | Diabetes | Metabolism
The Crewe lab uses transgenic mouse lines, cell culture and biochemistry to understand extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation. Our work has uncovered the existence of an expansive EV-mediated signaling network within the adipose tissue proper, and from the adipose tissue to other organs. This mostly adipocyte-derived EV population consists of exosome-like vesicles that carry proteins, RNAs and lipid species that can modulate a variety of signaling pathways in recipient cells. The focus of the lab is to determine how the various cargo of adipocyte EVs signal within the adipose tissue and from the adipose tissue to distal organs to modulate metabolism in obesity.