2026 Dean’s Impact Award
Category: New
Chemotherapy-induced adipo-lineage cell senescence drives bone loss (Links to an external site)
Raut GK, Malachowski T, Melam A, Ramalho-Oliveira R, Holt T, Luo X, Yao Z, Faget DV, Ren Q, DeNardo DG, Stewart SA
Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING (Links to an external site)
Cheng C, Lu HT, Li S, You Z
Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism (Links to an external site)
Chembo J, Bowman BM, Lapak K, Wilkerson E, Wamsley NT, Paiboonrungruang C, Cho K, Medcalf MR, Wang H, Patti GJ, Dolle RE, Chen X, Zolkind P, Major MB Chembo J, Bowman BM, Lapak K, Wilkerson E, Wamsley NT, Paiboonrungruang C, Cho K, Medcalf MR, Wang H, Patti GJ, Dolle RE, Chen X, Zolkind P, Major […]
A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth (Links to an external site)
Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton […]
Mutations in Hsp40 co-chaperone change the canonical interdomain interactions stimulating LGMDD1 myopathy (Links to an external site)
Ankan Bhadra, Geetika Aggarwal, Anshuman Jaysingh, Jil Daw, Conrad C. Weihl and Heather True
ACAD10 and ACAD11 enable mammalian4-hydroxy acid lipid catabolism (Links to an external site)
Edrees H. Rashan, Abigail K. Bartlett, Daven B. Khana, Jingying Zhang,Raghav Jain, Gina Wade, Luciano A. Abriata, Andrew J. Smith,Zakery N. Baker, Taylor Cook, Alana Caldwell, Autumn R. Chevalier,Patrick Forny, Brian F. Pfleger, Matteo Dal Peraro, Peng Yuan,Daniel Amador-Noguez, Judith A. Simcox, & David J. Pagliarini
The essential calcium channel of sperm CatSper is temperature-gated (Links to an external site)
Swain, D.K., Vergara, C., Castro-Arnau, J., Lishko, Polina
“ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation” (Links to an external site)
Subhajit Poddar, Samuel D. Chauvin, Christopher H. Archer, Wei Qian, Jean A. Castillo-Badillo, Xin Yin, W. Miguel Disbennett, Catherine A. Miner, Joe A. Holley, Teresa V. Naismith, W. Alexander Stinson, Xiaochao Wei, Yue Ning, Jiayuan Fu, Trini A. Ochoa, Nehalee Surve, Shivam A. Zaver, Kimberly A. Wodzanowski, Katherine R. Balka, Rajan Venkatraman, Canyu Liu, Kelly […]
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks (Links to an external site)
Ning Tsao, Patrick M. Lombardi, Ajin Park, Jennifer Olabode, Rebecca Rodell, Hua Sun, Shilpa Padmanaban, Joshua Brinker, Miaw-Sheue Tsai, Elizabeth A. Pollina, Chun-Kan Chen, Nima Mosammaparast