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Category: Major MB

Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism (Links to an external site)

December 19, 2025December 19, 2025

Chembo J, Bowman BM, Lapak K, Wilkerson E, Wamsley NT, Paiboonrungruang C, Cho K, Medcalf MR, Wang H, Patti GJ, Dolle RE, Chen X, Zolkind P, Major MB Chembo J, Bowman BM, Lapak K, Wilkerson E, Wamsley NT, Paiboonrungruang C, Cho K, Medcalf MR, Wang H, Patti GJ, Dolle RE, Chen X, Zolkind P, Major […]

A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth (Links to an external site)

December 19, 2025December 19, 2025

Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton […]

Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2 (Links to an external site)

December 15, 2023December 15, 2023

LaPak KM, Saeidi S, Bok I, Wamsley NT, Plutzer IB, Bhatt DP, Luo J, Ashrafi G, and Major MB

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC (Links to an external site)

September 15, 2023September 15, 2023

Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le Q-T, Goldfarb D, and Major MB

Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1γ3 in WNT signaling (Links to an external site)

June 1, 2022February 27, 2023

Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB

Protein proximity networks and functional evaluation of the Casein Kinase 1 γ family reveals unique roles for CK1γ3 in WNT signaling (Links to an external site)

June 1, 2022February 27, 2023

Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, and Major MB

Department of Cell Biology & Physiology

Washington University School of Medicine

660 S. Euclid Ave.

MSC-8228-03-04

St. Louis, MO 63110

314-273-8536

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