Ghazaleh Ashrafi, PhD

Ghazaleh Ashrafi, PhD

Assistant Professor of Cell Biology & Physiology

The Ashrafi lab uses genetic, biochemical, and quantitative optical imaging techniques to study metabolic regulation of neurotransmission.

Research Interests

The Ashrafi lab uses genetic, biochemical, and quantitative optical imaging techniques to study metabolic regulation of neurotransmission. The brain is the most energy consuming organ of the body and is highly sensitive to energetic perturbations. A significant fraction of this energy is consumed at nerve terminals for neurotransmission. However, regulatory mechanism that modulate energy metabolism at nerve terminals are poorly understood. The overall goal of the lab is to uncover novel molecular regulators of glycolysis and mitochondrial metabolism and elucidate their role in axonal degeneration and neurodegenerative disease. To this end, we use state-of-the-art optical indicators for ATP and other metabolites and monitor synaptic activity in single synapses to gain quantitative insight into presynaptic metabolic regulation.

Professional Education
  • BSc: University of Alberta, 2009, Cell Biology
  • PhD: Harvard University, 2014, Biochemistry
  • Postdoc: Weill Medical College of Cornell University, 2014-2019, Neurobiology

Ashrafi Lab

McDonnell Sciences Building (MS: 8228-0012-05)
314-362-5518
ghazaleh@wustl.edu

Neurotransmission | Neurometabolism | Glycolysis | Mitochondrial Function | Synaptic Imaging | Neurodegeneration | Epilepsy

The overarching goal of the Ashrafi lab is to interrogate the metabolic regulation of synaptic transmission. We combine state-of-the-art imaging of single synapses with proteomic and genomic analysis to determine how metabolic pathways are regulated in the nervous system. We also investigate the dysregulation of mitochondrial and glycolytic energy metabolism in a variety of neurological disorders such as Parkinson’s disease and epilepsy

Publications