Blumer Lab

Tumor Cell Signaling | Metabolomics | Proteomics | Transcriptomics | CRISPR screens | Molecular and Whole-Animal Imaging | Single-Molecule Biophysics | Targeted Therapy Development | Synthetic Organic Chemistry

The Blumer lab studies oncogenic signaling by mutationally activated heterotrimeric G proteins. Our ongoing research: 1) determines how oncogenic G proteins drive tumor formation, growth, invasion, survival, and metabolism; 2) establishes oncogenic G proteins as pharmacological targets for cancer therapy; and 3) designs and synthesizes G protein inhibitors for preclinical studies and, eventually, clinical trials. Much of our work focuses on metastatic uveal (ocular) melanoma because it is highly aggressive, deadly and untreatable, and nearly always driven by oncogenic G proteins