News

New Publication for Djuranovic Lab

Laura L. Arthur and Sergej Djuranovic.  PolyA tracks, polybasic peptides, poly-translational hurdles.  WIREs RNA. (2018) https://onlinelibrary.wiley.com/doi/abs/10.1002/wrna.1486.

Abstract:  The abundance of messenger RNA (mRNA) is one of the major determinants of protein synthesis. As such, factors that influence mRNA stability often contribute to gene regulation.  Polyadenylation of the 3' end of mRNA transcripts, the poly(A) tail, has long been recognized as one of these regulatory elements given its influence on translation efficiency and mRNA stability.  Unwanted translation of the poly(A) tail signals to the cell an aberrant polyadenylation event or the lack of stop codon, which makes this sequence an important element in translation fidelity and mRNA surveilance response.  Consequently, investigations into the effects of the poly(A) tail lead to the discoveries that poly-lysine as well as other polybasic peptide sequences and, to a much greater extent, polyA mRNA sequences within the open reading frame influence mRNA stability and translational efficiency.  Conservation and evolutionary selection of codon usage in polyA track sequences across multiple organisms suggests a biological significance for coding polyA tracks in the regulation of gene expression.  Here, we discuss the cellular responses and consequences of coding polyA track translation and synthesis of polybasic peptides.


Congratulations to Michael Skowyra and the Hanson Lab on their New Science Publication

Michael L. Skowyra, Paul H. Schlesinger, Teresa V. Naismith, Phyllis I. Hanson.  Triggered recruitment of ESCRT machinery promotes endolysosomal repair.  Science 360 (2018) DOI:10.1126/science.aar5078.

A quick fix for leaky endosysomes:  Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network.  Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health.  Skowrya et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrex and Carlton).  The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function.  The ESCRT activity is distinct from organelle disposal pathways.  These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates.

Read the full article at, http://dx.doi.org/10.1126/science.aar5078.


Academy of Science of St. Louis Honors John E. Heuser, M.D.

Congratulations to Dr. John Heuser! John E. Heuser, M.D., Professor Emeritus of Cell Biology and Physiology at…
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New Review Article for Huettner in the Journal of Physiology

Jim Huettner's invited review article titled Glutamate Receptor Pores is available on the Journal of Physiology 's…
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Sparks awarded Cancer Biology Pathway Fellowship and NSF Fellowship

Melanie Sparks has just been awarded a Cancer Biology Pathway Fellowship from the Siteman Cancer Center. …
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Heuser named winner of the 2014 E.B. Wilson Medal

John E. Heuser, M.D., Emeritus Professor of Cell Biology and Physiology, will receive the E.B. Wilson…
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Congratulations to Dr. Zhongsheng You on his new publication in Nature Medicine!

You Lab findings reported in Nature Medicine. Dr. You and his team have uncovered a novel link between…
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Introducing Dr. Fitzpatrick, WUCCI Scientific Director

James Fitzpatrick, PhD, joined the School of Medicine on June 1, 2015 as the inaugural scientific director of the Washington…
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New Klyachko publication in Neuron

Dr. Vitaly Klyachko, with colleagues from UCLA and Northwestern, has just published a review on Fragile X syndrome…
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Piston named AAAS Fellow

David W. Piston, Ph.D., Edward Mallinckrodt, Jr. Professor and Head of the Department of Cell Biology and…
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New Hanson Publication in Science

Congratulations to Phyllis Hanson and team on their new Science publication! McCullough, J, Clippinger, AK, Talledge, N, Skowyra,…
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“BPS Society TV” at 60th Annual Meeting in Los Angeles, CA

At the Biophysical Society’s 60th Annual Meeting in Los Angeles in February 2016, the Society partnered…
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New Publication for You Lab

Congratulations to Sharad Paudyal and Zhongsheng You on their new publication in Acta Biochim Biophys Sin (Shanghai). Paudyal,…
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New Piston Lab Publication in Nature Methods

Congratulations to Dave Piston and his lab on their new publication in Nature Methods! Cranfill, PJ, Sell, BR,…
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Work by Vivian Lee and Carmen Halabi in the Mecham lab helps explain how a genetic error in the lysyl oxidase gene increases risk of aortic rupture.

Congratulations to Vivian Lee, graduate student in Dr. Robert Mecham's lab for having her work published in…
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Cheruiyot Awarded 2016 HHMI International Student Research Fellowship

We are pleased to announce that Abigael Cheruiyot, graduate student in Dr. Zhongsheng You’s lab, has…
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New Publication for Lavagnino and the Piston Lab.

Congratulations to Dr. Zeno Lavagnino and the Piston lab group on their new publication in Biophysical Journal! Zeno…
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Microscopy Society of America Announces 2017 Major Award Winners

David W. Piston, PhD, Edward J. Mallinckrodt Jr. Professor of Cell Biology & Physiology, Physics, and Bioengineering at…
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