New Publication for Djuranovic Lab

Laura L. Arthur and Sergej Djuranovic.  PolyA tracks, polybasic peptides, poly-translational hurdles.  WIREs RNA. (2018)

Abstract:  The abundance of messenger RNA (mRNA) is one of the major determinants of protein synthesis. As such, factors that influence mRNA stability often contribute to gene regulation.  Polyadenylation of the 3' end of mRNA transcripts, the poly(A) tail, has long been recognized as one of these regulatory elements given its influence on translation efficiency and mRNA stability.  Unwanted translation of the poly(A) tail signals to the cell an aberrant polyadenylation event or the lack of stop codon, which makes this sequence an important element in translation fidelity and mRNA surveilance response.  Consequently, investigations into the effects of the poly(A) tail lead to the discoveries that poly-lysine as well as other polybasic peptide sequences and, to a much greater extent, polyA mRNA sequences within the open reading frame influence mRNA stability and translational efficiency.  Conservation and evolutionary selection of codon usage in polyA track sequences across multiple organisms suggests a biological significance for coding polyA tracks in the regulation of gene expression.  Here, we discuss the cellular responses and consequences of coding polyA track translation and synthesis of polybasic peptides.

Congratulations to Michael Skowyra and the Hanson Lab on their New Science Publication

Michael L. Skowyra, Paul H. Schlesinger, Teresa V. Naismith, Phyllis I. Hanson.  Triggered recruitment of ESCRT machinery promotes endolysosomal repair.  Science 360 (2018) DOI:10.1126/science.aar5078.

A quick fix for leaky endosysomes:  Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network.  Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health.  Skowrya et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrex and Carlton).  The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function.  The ESCRT activity is distinct from organelle disposal pathways.  These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates.

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